This wiki is not the appropriate place to seek support with game bugs but the following info can help you find help in case you arrived here first.
Please note that reports involving modified games will be ignored by Egosoft. There are so many opportunities for wild-goose chases, it's not worth their time if we have not invested a bit of time ourselves trying to narrow down whether the issue is present in unmodified (AKA "vanilla") games or not.
Problems in unmodified (AKA "vanilla") games
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If successful in finding the cause, you can then ask for help in the thread relating to the extension or save edit. If unable to work out what extension may be the cause, you could try asking in the thread of one of mods that people have posted in recently but it's a bit of a long shot. You can find information on where threads about extensions can be found here.
Please note that even after turning off or uninstalling an extension, or reversing a save edit, the save will still be considered modified.